By Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro
This authoritative quantity offers a holistic photograph of antibody-drug conjugates (ADCs). Fourteen finished chapters are divided into six sections together with an advent to ADCs, the ADC build, improvement matters, panorama, IP and pharmacoeconomics, case experiences, and the way forward for the sector. The publication examines every little thing from the choice of the antibody, the drug, and the linker to a dialogue of developmental concerns similar to formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory demanding situations. It additionally explores pharmacoecomonics and highbrow homes, together with lately issued patents and the fee research of drug remedy. Case experiences are provided for the 3 ADCs that experience acquired FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), in addition to an ADC in late-stage scientific trials, glembatumumab vedotin (CDX-011). ultimately, the quantity provides a viewpoint by way of the editors at the destiny instructions of ADC improvement and medical functions. Antibody-Drug Conjugates is a pragmatic and systematic source for scientists, professors, and scholars drawn to increasing their wisdom of state of the art examine during this fascinating field.
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Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (AAPS Advances in the Pharmaceutical Sciences Series) by Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro